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ORIGINAL ARTICLE
Year : 2019  |  Volume : 11  |  Issue : 6  |  Page : 274-277

Assessment of oral mucosal integrity status in patients with recurrent aphthous stomatitis


1 Department of Dentistry, Vinayaka Mission’s Medical College, Vinayaka Mission’s Research Foundation (Deemed To Be University), Karaikal, Puducherry, India
2 Department of Oral and Maxillofacial Pathology, Chettinad Dental College and Research Institute, Tamil Nadu Dr.MGR Medical University, Kelambakkam, Tamil Nadu, India
3 Department of Oral and Maxillofacial Surgery, Vinayaka Mission’s Sankarachariyar Dental College, Vinayaka Mission’s Research Foundation (Deemed To Be University), Salem, Tamil Nadu, India
4 Department of Oral and Maxillofacial Surgery, Raja Muthiah Dental College and Hospital, Annamalai University,Chidambaram, Tamil Nadu, India
5 Department of Prosthodontics, Raja Muthiah Dental College and Hospital, Annamalai University,Chidambaram, Tamil Nadu, India
6 Department of Public Health Dentistry, Indira Gandhi Institute of Dental Sciences, Sree Balaji Vidyapeeth (Deemed To Be University), Pillayarkuppam, Puducherry, India

Correspondence Address:
Dr. Sriram Kaliamoorthy
Department of Dentistry, Vinayaka Mission’s Medical College, Vinayaka Mission’s Research Foundation (Deemed To Be University), Karaikal, Puducherry 609609
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JPBS.JPBS_10_19

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Background: Recurrent aphthous stomatitis represents one of the most common oral pathoses with multifactorial etiology. Decrease in mucosal barrier resistance is believed to be one of the etiologies in its pathogenesis. This study was conducted to assess the oral mucosal integrity status by evaluating the salivary albumin level in patients with aphthous stomatitis. Materials and Methods: Thirty patients diagnosed with aphthous stomatitis were selected as case group. Equal number of age- and sex-matched healthy individuals formed the control group. Salivary albumin level was estimated during active and quiescent stage of the disease in both case group and control group. Result: Mean salivary albumin level for the case group during the active and quiescent stage was 0.070g/dL (SD = 0.037) and 0.004g/dL (SD = 0.007) (SPSS, version 7.0), respectively, and that for the control group was 0.027g/dL (SD =0.042). Statistically significant difference was found on comparison of the mean salivary albumin level between the case group during active and quiescent stage and the normal controls using Mann–Whitney U test. No statistically significant difference in salivary albumin level was seen between the quiescent stage in case group and the normal controls. Conclusion: Increase in salivary albumin level at the time of disease presentation could be attributed to the leakage of albumin through the ulcerated mucosa. Absence of significant elevation in the salivary albumin level after the resolution of the aphthous ulcer apparently indicates inherently a healthy mucosal barrier in majority of the patients.


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