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ORIGINAL ARTICLE
Year : 2019  |  Volume : 11  |  Issue : 6  |  Page : 301-304

Gingival crevicular fluid levels of RANKL and OPG after placement of collagen membrane with simvastatin in the treatment of intrabony defects in chronic periodontitis


1 Department of Periodontics JKK Nattraja Dental College and Hospital, Komarapalayam, Tamil Nadu, India
2 Department of Oral Surgery, JKK Nattraja Dental College and Hospital, Komarapalayam, Tamil Nadu, India
3 Department of Endocrinology, Post Graduate Institute of Basic Medical Sciences (PGIBMS), University of Madras, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. Thangakumaran Suthanthiran
Department of Periodontics, JKK Nattraja Dental College and Hospital, Komarapalayam 638183, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JPBS.JPBS_18_19

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Purpose: The aim of this study was to estimate the Receptor activator of nuclear factor kappa-B ligand (RANKL) and Osteoprotegrin (OPG) levels in gingival crevicular fluid (GCF) after placement of collagen membrane with simvastatin in intrabony defects. Materials and Methods: Sixty subjects were grouped according to the treatment plan as Group I and Group II. Group I included patients with intrabony defects treated with collagen membrane. Group II included patients with intrabony defects treated with simvastatin of 1.5mg concentration incorporated into the collagen membrane. A split-mouth design was planned, in which two contralateral sites with >5mm probing pocket depth and radiographic evidence of bone loss at baseline were chosen. Probing pocket depth was standardized with acrylic stent in all the selected areas. GCF samples were collected at baseline and 21 days. The amount of RANKL and OPG in the samples was determined by commercial ELISA kits (Biomedica Medizinprodukte, Austria). Results: When comparing both the groups, Group II had more statistically significant (P < 0.001**) decrease in the levels of RANKL than Group I. In contrast to RANKL, the OPG levels were significantly increased in patients (Group II) having intrabony defects treated with collagen membrane along with simvastatin. Conclusion: Simvastatin-loaded collagen membrane expressed increased OPG and decreased RANKL levels, which could have a potential role in periodontal regeneration.


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