The early mortality rate of people infected with coronavirus (COVID-2019) in Wuhan, China: Review of three retrospective studies
Asim Ahmed Elnour1, Judit Don2, Isra Yousif3, Kishore Gnana1, Semira Abdi1, Noora Al Hajri4, Abdulla Al Amoodi5, Ahmed Ibrahim Fathelrahman6, Salma Mohammed Magboul7, Sasha Mohamed8, Sahar Asim Ahmed9, Adel Sadeq10
1 Pharmacy Practice, College of Pharmacy, Gulf Medical University, Ajman, UAE
2 College of Pharmacy, Gulf Medical University, Ajman, UAE
3 Clinical Pharmacist, Omdurman Islamic University, Omdurman, Sudan
4 Department of Epidemiology and Population Health, Khalifa University, Abu Dhabi, UAE
5 Ambulatory Healthcare Services, Academic Affairs, Abu Dhabi Health Services (SEHA), Abu Dhabi, UAE
6 Department of Clinical Pharmacy, College of Pharmacy, Taif University, Riyadh, Saudi Arabia
7 Department of Pharmacist, College of Pharmacy, Khartoum University, Khartoum, Sudan
8 Clinical pharmacy, College of Pharmacy, Riyadh Elm University, Riyadh, Saudi Arabia
9 Dentist, MySmile Dental Clinic, Dubai, UAE
10 Assistant Professor, Program of Clinical Pharmacy, College of Pharmacy, Al Ain University, Al Ain, UAE
Prof. Asim Ahmed Elnour
Pharmacy Practice, College of Pharmacy, Gulf Medical University, Ajman.
Source of Support: None, Conflict of Interest: None
Background: The infection with coronavirus and non-survivor cases have been escalated since the first inception between January and March 2020. Therefore, reviewing the collated clinical characteristics of non-survivors might assist in current preventive efforts, triaging, and management of survivors. The aim of this review was to summarize the clinical characteristics of non-survivor cases due to the infection caused by a novel coronavirus and to identify the relevant data that might put the new cases at increased mortality. Materials and Methods: We have identified three published articles on novel coronavirus reported during December 01, 2019, to March 15, 2020, which have described the mortality rate in Wuhan, Hubei, China. Results: The mean duration of studies (i.e., the three retrospective studies with 278 cases) was 24.7 days, and the duration of onset to dyspnea was variable between 8 and 5 days. The main reported complications were acute respiratory distress, pneumonia, acute kidney injury, and acute cardiac disease. The overall major comorbidity reported was cardiovascular diseases at 23.7% (66 of 278). The reported overall mortality rate was 8.3% (23 of 278), with the highest mortality rate of 15.0% (6 of 41) reported in Jin Yintan Hospital at Wuhan city. Conclusions: The clinical characteristics of the non-survivors from the novel coronavirus included adult males, aged older than 50 years, having comorbidities of cardiovascular disease, respiratory distress syndrome, acute kidney injury, and diabetes with higher admission to the intensive care unit. The mortality rate was high in two of the reported studies (15.0% and 11.0%), which was decreased in the later-dated study to 3.4%.