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Year : 2020  |  Volume : 12  |  Issue : 5  |  Page : 228-232

Evaluation of effectiveness of intracanal medicaments on viability of stem cells of apical papilla

1 Department of Conservative Dentistry and Endodontics, Saraswati Dental College, Lucknow, Uttar Pradesh, India
2 Department of Conservative Dentistry and Endodontics, King George’s Medical University, Lucknow, Uttar Pradesh, India
3 Department of Conservative Dentistry and Endodontics, BBD College of Dental Sciences, Lucknow, Uttar Pradesh, India
4 Department of Oral and Maxillofacial Surgery, Saraswati Dental College, Lucknow, Uttar Pradesh, India

Correspondence Address:
Gaurav Jain
Associate Professor, Department of Conservative Dentistry and Endodontics, Saraswati Dental College, 233, Tiwari Ganj, Faizabad Road, Lucknow 227105, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jpbs.JPBS_67_20

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Introduction: Regeneration, in the field of endodontics, is the process of restoring and maintaining both architectural form and biological functions of damaged tooth. Presently, regenerative endodontics is not hypothetical and is an alternative to conventional apexification procedures. There is a deficient knowledge concerning the role of intracanal medicaments and their effect on dental stem cells. Aim: The aim of this study was to evaluate the effectiveness of commonly used intracanal medicaments on the viability of dental stem cells of the apical papilla (SCAPs). Materials and Methods: SCAPs were cultured and subjected to various concentrations including triple antibiotic paste, double antibiotic paste, Augmentin, and calcium hydroxide (Ca(OH)2). Viable percentage of stem cell counts was obtained 3 days after treatment. Results: All three antibiotics used hereby significantly decreased SCAP cell survival at particular concentrations, whereas Ca(OH)2 showed stimulating effect on SCAP survival. Conclusion: As per results obtained within limitations of this study, use of Ca(OH)2 in regenerative endodontics in comparison to different commonly used antimicrobial combinations is recommended. Hereby, for clinical use, we suggest adequate concentrations of antimicrobials with adequate antibacterial efficacy should be used.

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