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Year : 2020  |  Volume : 12  |  Issue : 5  |  Page : 37-42

The association of matrix metalloproteinase gene polymorphisms and periodontitis: An overview

1 Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia
2 Ministry of Health, Riyadh, Saudi Arabia
3 Prince Sultan Military Medical City, Riyadh, Saudi Arabia
4 Department of Preventive Dental Sciences, College of Dentistry, Dar Al Uloom University, Riyadh, Saudi Arabia
5 Department of Periodontics, Sri Sai College of Dental Surgery, Vikarabad, Telangana, India

Correspondence Address:
Dalal H Alotaibi
Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, King Saud University, Riyadh 11451
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jpbs.JPBS_136_20

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Periodontitis is a multifactorial inflammatory disease, pathogenic bacteria being the primary etiological agents. The host response and the severity of clinical manifestation are determined by genetic and environmental factors. There is some evidence that the individual response to environmental variations in the immune response in periodontitis is associated with genetic factors. Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes located in the extracellular matrix. Their primary function is the breakdown of connective tissue components. Their role in the oral cavity is very vital. In this literature review, we summarized the contemporary knowledge on the function of MMPs in oral cavity and periodontal disease.

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