Assessment of efficacy of 5% topical amlexanox and 0.1% topical triamcinolone acetonide in management of recurrent aphthous stomatitis
Kumari Kavita1, Rohit Singh2, Revati Singh3, Sudhir Gonuguntla4, Alexander Maniangat Luke5, Harshvardhan Shridhar Jois6
1 Department of Dentistry, Nalanda Medical College and Hospital, Patna, Bihar, India
2 Department of Prosthodontics, Crown, Bridge and Implantology, Patna Dental College & Hospital, Patna, Bihar, India
3 Department of Dentistry, Patna Medical College and Hospital (PMCH), Patna, Bihar, India
4 Department of Oral and Maxillofacial Pathology, Malla Reddy Institute of Dental Sciences, Hyderabad, Telangana, India
5 Department of Surgical Sciences, College of Dentistry, Ajman University, Ajman, UAE
6 Department of Oral Pathology, Army College of Dental Sciences, Secunderabad, Telangana, India
Department of Prosthodontics, Crown, Bridge and Implantology, Patna Dental College & Hospital, Ashok Rajpath Road, Patna, Bihar.
Source of Support: None, Conflict of Interest: None
Aim: The aim of this study was to assess the efficacy of 5% topical amlexanox and 0.1% topical triamcinolone acetonide in recurrent aphthous stomatitis (RAS) management. Materials and Methods: Sixty adult patients of RAS of both genders were divided into two groups with each group having 30 patients. In group I, 0.1% topical triamcinolone acetonide was prescribed. In group II, 5% topical amlexanox was prescribed. Patients were recalled regularly and size of ulcer, erythema, and pain score was recorded on days 1, 3, and 5. Results: The mean ulcer size (mm) on day 1 in group I was 4.3 and in group II it was 4.1, on day 3 it was 3.5 in group I and in group II it was 3.6, on day 5 in group I it was 1.3 and in group II it was 1.7. The result was not statistically significant (P > 0.05). The mean pain score recorded on visual analog scale was in descending grade day by day on first, third, and fifth days. In group I, healing was seen in 29 (96.6%) patients and in 28 (93.3%) patients in group II. Partially healing was seen in 1 (3.3%) patient in each group, whereas in group II nonhealing was observed in 1 (3.3%) patient. The statistical significance was not achieved as P > 0.05. Conclusion: Authors found that above drugs were effective in reducing pain, size of ulcer, erythema, and improving healing in patients with recurrent aphthous stomatitis. There were better results with triamcinolone acetonide as comparison of amlexanox.