Journal of Pharmacy And Bioallied Sciences
Journal of Pharmacy And Bioallied Sciences Login  | Users Online: 2690  Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size 
    Home | About us | Editorial board | Search | Ahead of print | Current Issue | Past Issues | Instructions | Online submission


ORIGINAL ARTICLE
Year : 2021  |  Volume : 13  |  Issue : 4  |  Page : 380-386

In vivo pharmacological testing of herbal drugs for anti-allergic and anti-asthmatic properties


1 Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University; Saudi Toxicology Society, Faculty of Medicine, Umm Al-Qura University, Holy Makkah, Saudi Arabia; Department of Pharmacology, Singhania Hospital and Research Centre, Singhania University, Jhunjhunu, Rajasthan, India
2 Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University; Saudi Toxicology Society, Faculty of Medicine, Umm Al-Qura University, Holy Makkah, Saudi Arabia
3 Formulation Development, Dabur Research Foundation, Ghaziabad, Uttar Pradesh, India
4 Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Holy Makkah, Saudi Arabia
5 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt

Correspondence Address:
Dr. Naiyer Shahzad
Department of Pharmacology, Singhania Hospital and Research Centre, Singhania University, Pacheri Bari, Jhunjhunu – 333 515, Rajasthan

Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jpbs.jpbs_454_21

Rights and Permissions

Background: Asthma is a chronic inflammatory disease characterized by reversible airway obstruction, hyperresponsiveness, and remodeling. Asthma prevalence has increased significantly globally over the last decade, and it remains incurable to this date. Aims and Objectives: The present study evaluated some of the antiasthmatic medicinal plants to assess their mode of action. Materials and Method: Animal models for milk-induced leukocytosis, milk-induced eosinophilia, mast cell degranulation, clonidine-induced catalepsy, and active paw anaphylaxis were used to assess the pharmacological effects of Ammi visnaga, Medicago sativa, and Urtica dioica. Results: Mice pretreated with diazepam, methanolic extract of M. sativa, and U. dioica exhibited significant (P < 0.05) inhibition in milk-induced leukocytosis. However, only M. sativa showed statistically significant (P < 0.05) results. All plants showed a statistically significant (P < 0.05) tendency to decrease milk-induced eosinophilia. Methanolic extracts of all plants significantly (P < 0.05) protected mast cells against degranulation by clonidine. A. visnaga and U. dioica significantly (P < 0.05) protected mice against clonidine-induced catalepsy. An acute treatment by M. sativa potentiated the catalepsy, while it significantly inhibited the catalepsy (P < 0.05) upon chronic treatment. In the allergic inflammation model, methanolic extracts of all plants under study decreased paw thickness in a statistically significant manner (P < 0.05). Conclusion: All the three plants in this study demonstrated anti-inflammatory and antihistaminic effects, as well as decreased paw thickness, validate anti-allergic properties. A. visnaga showed a mast cell-stabilizing effect. A. visnaga and U. dioica inhibited the histamine-mediated clonidine-induced catalepsy from mast cells which proves the antihistaminic activity of these plants.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

suppl
 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1366    
    Printed8    
    Emailed0    
    PDF Downloaded165    
    Comments [Add]    

Recommend this journal