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ORIGINAL ARTICLE
Year : 2021  |  Volume : 13  |  Issue : 6  |  Page : 1573-1576

Assessment of correlation of oxidative stress and insulin resistance with glucose-6-phosphate dehydrogenase activity in Type II diabetes mellitus patients


1 Department of Biochemistry, Career Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
2 Department of Biochemistry, KGMU, Lucknow, Uttar Pradesh, India

Correspondence Address:
Shweta Kumari
Department of Biochemistry, KGMU, Lucknow, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jpbs.jpbs_291_21

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Background: The present study aimed to assess the correlation of oxidative stress glucose-6-phosphate dehydrogenase (G6PD) activity in type II diabetes mellitus (DM) patients. Methodology: Forty-eight type II DM patients and healthy subjects were recruited. In all, G6PD activity, protein carbonyl, and total thiol levels were measured. Results: The mean glycated hemoglobin (HbA1c) was 9.4% in Group I and 5.2% in Group II, G6PD activity was 6.5 U/gHb in Group I and 8.2 U/gHb in Group II, protein carbonyl was 14.2 nmol/mg protein in Group I and 3.5 nmol/mg protein in Group II, and total thiol level was 204.7 μmol/mL in Group I and 318.2 μmol/mL in Group II. In Group I, G6PD activity positively correlated with total thiol (r = 0.62) and negatively correlated with protein carbonyl (r = −0.73) and HbA1C (r = −0.67), protein carbonyl positively correlated with HbA1C (r =0.45) and negatively correlated with total thiol (r = −0.84), and total thiol negatively correlated with HbA1c (r = −0.30). Conclusion: G6PD may be considered a biomarker of oxidative stress and poor glycemic control in diabetic patients.


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