Journal of Pharmacy And Bioallied Sciences

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 2  |  Issue : 2  |  Page : 118--120

Comparative bioavailability studies of citric acid and malonic acid based aspirin effervescent tablets


Anju Gauniya1, Sanjita Das1, Subrata Mallick2, SP Basu1 
1 Department of Phramaceutical Technology, Noida Institute of Engg. and Technology, Greater Noida, India
2 Department of Pharmaceutics School of Pharmaceutical Sciences, Bhubneshwer, Orrisa, India

Correspondence Address:
Anju Gauniya
Department of Phramaceutical Technology, Noida Institute of Engg. and Technology, Greater Noida
India

Purpose: The present investigation is aimed at comparing the pharmacokinetic profile (Bioavailability) of aspirin in tablet formulations, which were prepared by using different effervescent excipients such as citric acid and malonic acid. Materials and Methods: The relative bioavailability and pharmacokinetics of citric acid based aspirin effervescent tablet (Product A) and malonic acid based aspirin effervescent tablet (Product B) formulations were evaluated for an in-vitro dissolution study and in-vivo bioavailability study, in 10 normal healthy rabbits. The study utilized a randomized, crossover design with a one-week washout period between doses. Blood samples were collected at 0, 1, 2, 4, 6, 8, 12 and 24 hours following a 100 mg/kg dose. Plasma samples were assayed by High Performance Liquid Chromatography. T max , C max , AUC 0-24 , AUC 0- ∞, MRT, K a, and relative bioavailability were estimated using the traditional pharmacokinetic methods and were compared by using the paired t-test. Result: In the present study, Products A and B showed their T max , C max , AUC 0-24 , AUC 0- ∞, MRT, and K a values as 2.5 h, 2589 ± 54.79 ng/ml, 9623 ± 112.87 ng.h/ml, 9586 ± 126.22 ng.h/ml, 3.6 ± 0.10 h, and 0.3698 ± 0.003 h -1 for Product A and 3.0 h, 2054 ± 55.79 ng/ml, 9637 ± 132.87 ng.h/ml, 9870 ± 129.22 ng.h/ml, 4.76 ± 0.10 h, and 0.3812 ± 0.002 h -1 for Product B, respectively. Conclusion: The results of the paired t-test of pharmacokinetics data showed that there was no significant difference between Products A and B. From both the in vitro dissolution studies and in vivo bioavailability studies it was concluded that products A and B had similar bioavailability.


How to cite this article:
Gauniya A, Das S, Mallick S, Basu S P. Comparative bioavailability studies of citric acid and malonic acid based aspirin effervescent tablets.J Pharm Bioall Sci 2010;2:118-120


How to cite this URL:
Gauniya A, Das S, Mallick S, Basu S P. Comparative bioavailability studies of citric acid and malonic acid based aspirin effervescent tablets. J Pharm Bioall Sci [serial online] 2010 [cited 2021 Jan 24 ];2:118-120
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2010;volume=2;issue=2;spage=118;epage=120;aulast=Gauniya;type=0