Journal of Pharmacy And Bioallied Sciences

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 3  |  Issue : 2  |  Page : 236--241

Antiulcer effect of the methanolic extract of Tamarindus indica seeds in different experimental models


Pankaj Kalra1, Sunil Sharma2, Suman2, Suresh Kumar2 
1 Rayat and Bahra Institute of Pharmacy, Mohali, Chandigarh, India
2 Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology Post Box: 38, Hisar, Haryana - 125001, India

Correspondence Address:
Suresh Kumar
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology Post Box: 38, Hisar, Haryana - 125001
India

Background: Peptic ulcer is a global health problem of the gastrointestinal tract characterized by mucosal damage secondary to pepsin and gastric acid secretion which occurs due to due to an imbalance between offensive and defensive factors. Objective: The present study was carried out with methanolic extract of the seed coat of Tamarindus indica Linn. to evaluate its antiulcer potential on ibuprofen, alcohol and pyloric ligation induced gastric lesions. Materials and Methods: Doses of 100 mg/kg & 200 mg/kg of methanolic extract wre administered orally to rats of different groups. Ranitidine at a dose of 50 mg/kg was used as a standard drug for these gastric ulcer models. The gastric content was collected and the volume was measured. The ulceration index was determined by examining the inner lining of each stomach. Furthermore, the effect was assessed by free acidity, pepsin activity, total carbohydrate (TC), protein content (PK). Result: The result showed that the methanolic extract of seed coats of Tamarindus indica significantly reduce the total volume of gastric juice, free and total acidity of gastric secretion (P < 0.01) in pylorus ligation induced ulcer model as is comparable with the standard drug ranitidine. There was also a significant reduction in ulcer index (P < 0.01) as compared to control group. Conclusion: The methanolic extracts of seed coat of Tamarindus indica can be used as a new source of antiulcer agent in animals.


How to cite this article:
Kalra P, Sharma S, Suman, Kumar S. Antiulcer effect of the methanolic extract of Tamarindus indica seeds in different experimental models.J Pharm Bioall Sci 2011;3:236-241


How to cite this URL:
Kalra P, Sharma S, Suman, Kumar S. Antiulcer effect of the methanolic extract of Tamarindus indica seeds in different experimental models. J Pharm Bioall Sci [serial online] 2011 [cited 2021 Jan 18 ];3:236-241
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2011;volume=3;issue=2;spage=236;epage=241;aulast=Kalra;type=0