Journal of Pharmacy And Bioallied Sciences

ORIGINAL/BRIEF
Year
: 2012  |  Volume : 4  |  Issue : 5  |  Page : 110--111

Formulation and evalution of montelukast sodium - chitosan based spray dried microspheres for pulmonary drug delivery


Rushi Panchal, Harsha Patel, Vishnu Patel, Pratik Joshi, Ankit Parikh 
 A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy, P. B. No. 19, Vallabh Vidyanagar, Indukaka Ipcowala College of Pharmacy, New V. V. Nagar, Dist.-Anand, Gujarat, India

Correspondence Address:
Rushi Panchal
A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy, P. B. No. 19, Vallabh Vidyanagar, Indukaka Ipcowala College of Pharmacy, New V. V. Nagar, Dist.-Anand, Gujarat
India

The objective of present work was to prepare microspheres of montelukast sodium using a natural polymer- chitosan by spray drying method by using glutaraldehyde as a cross linking agent. The microspheres were characterized for size, shape, dissolution, swelling and mucoadhesion. It was observed that, all microspheres were spherical in shape with narrow size distribution. Microspheres had mean particle size of 7-12 μm, with % encapsulation efficiency of 78-86%. The % yield was 32-49% and drug load was 48-53%. With the increase in proportion of chitosan in formulation mucoadhesive strength was increase and also increased in particle size of microspheres. As the drug:polymer ratio increase drug loading was increase and % encapsulation efficiency was also increase.


How to cite this article:
Panchal R, Patel H, Patel V, Joshi P, Parikh A. Formulation and evalution of montelukast sodium - chitosan based spray dried microspheres for pulmonary drug delivery.J Pharm Bioall Sci 2012;4:110-111


How to cite this URL:
Panchal R, Patel H, Patel V, Joshi P, Parikh A. Formulation and evalution of montelukast sodium - chitosan based spray dried microspheres for pulmonary drug delivery. J Pharm Bioall Sci [serial online] 2012 [cited 2022 Jul 3 ];4:110-111
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2012;volume=4;issue=5;spage=110;epage=111;aulast=Panchal;type=0