Journal of Pharmacy And Bioallied Sciences

ORIGINAL/BRIEF
Year
: 2012  |  Volume : 4  |  Issue : 5  |  Page : 74--76

Preliminary investigation tests of novel antifungal topical aerosol


M Monali Kapadia, ST Solanki, V Parmar, MM Thosar, SS Pancholi 
 Babaria Institute of Pharmacy, Varnama, Vadodara, Gujarat, India

Correspondence Address:
M Monali Kapadia
Babaria Institute of Pharmacy, Varnama, Vadodara, Gujarat
India

Spray formulation can minimize pain and irritation experience during the application of conventional dosage forms. Econazole Nitrate is an active ingredient of the aerosol concentrate to be used for twice-daily application because of its long durability in the superficial layers of the fungal infected skin. The aim of this study is preliminary investigation of Econazole Nitrate spray by varying the concentrations of different constituents of the spray. The ratios of Propylene glycol (PG) and isopropyl myristate (IPM) were selected as independent variables in 2 2 full factorial designs, keeping the concentration of solvent, co-solvent and propellant LPG constant. Aerosol also contained Ethanol as solvent and Isopropyl alcohol as co-solvent. All ingredients of the aerosol were packaged in an aluminum container fitted with continuous-spray valves. Physical properties evaluated for the Econazole Nitrate spray included delivery rate, delivery amount, pressure, minimum fill, leakage, flammability, spray patterns, particle image and plume angle. Glass containers were used to study incompatibility between concentrate and propellant due to the ease of visible inspection. Isopropyl myristate at lower concentrate showed turbidity, while at high concentration it met the requirements for aerosol and produced Econazole Nitrate spray with expected characteristics.


How to cite this article:
Kapadia M M, Solanki S T, Parmar V, Thosar M M, Pancholi S S. Preliminary investigation tests of novel antifungal topical aerosol.J Pharm Bioall Sci 2012;4:74-76


How to cite this URL:
Kapadia M M, Solanki S T, Parmar V, Thosar M M, Pancholi S S. Preliminary investigation tests of novel antifungal topical aerosol. J Pharm Bioall Sci [serial online] 2012 [cited 2022 Jun 30 ];4:74-76
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2012;volume=4;issue=5;spage=74;epage=76;aulast=Kapadia;type=0