Journal of Pharmacy And Bioallied Sciences

ORIGINAL/BRIEF
Year
: 2012  |  Volume : 4  |  Issue : 5  |  Page : 86--87

Optimization of fast disintegration tablets using pullulan as diluent by central composite experimental design


Dipil Patel, Musharraf Chauhan, Ravi Patel, Jayvadan Patel 
 Nootan Pharmacy College, Visnagar, India

Correspondence Address:
Dipil Patel
Nootan Pharmacy College, Visnagar
India

Abstract

The objective of this work was to apply central composite experimental design to investigate main and interaction effect of formulation parameters in optimizing novel fast disintegration tablets formulation using pullulan as diluents. Face centered central composite experimental design was employed to optimize fast disintegration tablet formulation. The variables studied were concentration of diluents (pullulan, X1), superdisintigrant (sodium starch glycolate, X2), and direct compression aid (spray dried lactose, X3). Tablets were characterized for weight variation, thickness, disintegration time (Y1) and hardness (Y2). Good correlation between the predicted values and experimental data of the optimized formulation methodology in optimizing fast disintegrating tablets using pullulan as a diluent.



How to cite this article:
Patel D, Chauhan M, Patel R, Patel J. Optimization of fast disintegration tablets using pullulan as diluent by central composite experimental design.J Pharm Bioall Sci 2012;4:86-87


How to cite this URL:
Patel D, Chauhan M, Patel R, Patel J. Optimization of fast disintegration tablets using pullulan as diluent by central composite experimental design. J Pharm Bioall Sci [serial online] 2012 [cited 2022 Aug 8 ];4:86-87
Available from: https://www.jpbsonline.org/text.asp?2012/4/5/86/94150


Full Text

Advances in novel drug delivery system aim to formulating a dosage form for convenient administration and to get better patient compliance. To fulfill these medical needs, pharmaceutical technologists have developed a novel oral dosage form known as Orally Disintegrating Tablets (ODTs) which disintegrate rapidly in saliva, usually in a matter of seconds, without the need to take it water. Drug dissolution and absorption as well as onset of clinical effect and drug bioavailability may be significantly greater than those observed from conventional dosage forms. Central composite designs are two level full factorial (2k) design augmented by a number of center points and other chosen runs. These designs are such that they allow the estimation of all the regression parameters required to fit a second order model to a given response. Central composite designs in which the axial points represent the mid levels for all but one of the factors are also referred to as face-centered central composite designs.

 Materials and Methods



Face centered central composite experimental design was employed to optimize fast disintegration tablet formulation. The variables studied were concentration of diluents (pullulan, X 1 ), superdisintigrant (sodium starch glycolate, X 2 ), and direct compression aid (spray dried lactose, X 3 ). Tablets were prepared by direct compression methods on rotary tablet press using flat plain- face punches. Tablets were characterized for weight variation, thickness, disintegration time (Y 1 ) and hardness (Y 2 ).

 Results and Discussion



Disintegration time was strongly affected by quadratic terms of pullulan, sodium starch glycolate and spray dried lactose. The positive value of regression coefficient for pullulan suggested that hardness increased with increased amount of pullulan. In general, disintegration of tablets has been reported to slow down with increase in hardness. However, in present study higher concentration of pullulan was found to improve tablet hardness without increasing the disintegration time. Thus, pullulan is proposed as suitable diluents to archive fast disintegrating tablets with sufficient hardness.

 Conclusion



In the present study it can be concluded that good correlation was obtained between the predicted values and experimental data of the optimized formulation methodology in optimizing fast disintegrating tablets using pullulan as a diluent. It was also observed that further increase the concentration of pullulan (diluents) increases the hardness without affecting disintegration time. [1],[2],[3],[4],[5]

 Acknowledgement



Authors acknowledge for the guidance Mr. Ravi Patel and help throughout work and to Hayashibra Co. Ltd., Okayama, Japan for the supply of the pullulan.

References

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