Journal of Pharmacy And Bioallied Sciences

ORIGINAL/BRIEF
Year
: 2012  |  Volume : 4  |  Issue : 5  |  Page : 8--9

Floating microspheres of valacyclovir HCl: Formulation, optimization, characterization, in vitro and in vivo floatability studies


Nilamgiri Goswami, Garima Joshi, Krutika Sawant 
 TIFAC Centre of Relevance and Excellence, M S University of Baroda, Vadodara, Gujarat, India

Correspondence Address:
Krutika Sawant
TIFAC Centre of Relevance and Excellence, M S University of Baroda, Vadodara, Gujarat
India

Floating microspheres are multiple unit Gastroretentive drug delivery systems. Valacyclovir hydrochloride (VCH) is L-valyl ester prodrug of acyclovir. VCH degrades in intestinal fluid. The objective was to develop floating microspheres of VCH to localise the drug at upper part of GIT, for improved absorption. Floating microspheres were prepared by W/O emulsification solvent evaporation method using Ethylcellulose (EC) as polymer. Particle size and % EE were 550.021±0.241 μm, 79.88±2.236% respectively. in vitro and in vivo floatability studies confirmed floating behaviour of microspheres. VCH loaded floating microspheres can be a suitable alternative to the conventional formulation, by localizing the drug at upper GIT.


How to cite this article:
Goswami N, Joshi G, Sawant K. Floating microspheres of valacyclovir HCl: Formulation, optimization, characterization, in vitro and in vivo floatability studies.J Pharm Bioall Sci 2012;4:8-9


How to cite this URL:
Goswami N, Joshi G, Sawant K. Floating microspheres of valacyclovir HCl: Formulation, optimization, characterization, in vitro and in vivo floatability studies. J Pharm Bioall Sci [serial online] 2012 [cited 2022 Jul 2 ];4:8-9
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2012;volume=4;issue=5;spage=8;epage=9;aulast=Goswami;type=0