Journal of Pharmacy And Bioallied Sciences

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 6  |  Issue : 3  |  Page : 167--179

Evaluation of a classical unani pharmacopeial formulation safoof-e-muhazzil in hyperlipidemia: A randomized, standard controlled clinical study


Umar Jahangir1, Asim Ali Khan1, Prem Kapoor2, Farhan Jalees3, Shaista Urooj4 
1 Department of Moalejat (Medicine), Faculty of Medicine (U), Jamia Hamdard, New Delhi, India
2 Department of Medicine, Hamdard Institute of Medical Sciences and Research, New Delhi, India
3 Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India
4 Department of AYUSH, LRIUM, CCRUM, Hamdard Nagar, New Delhi, India

Correspondence Address:
Umar Jahangir
Department of Moalejat (Medicine), Faculty of Medicine (U), Jamia Hamdard, New Delhi
India

Aim of the Study: The aim of the following study is to evaluate the efficacy and tolerability of a compound Unani formulation in hyperlipidemia on clinical and biochemical parameters. Materials and Methods: A total of 90 patients with total cholesterol level of 220 mg/dl and above were included. In Group SQASQ thirty patients with total cholesterol 243.5 ± 5.294 mg/dl received Unani formulation safoof-e-muhazzil (SM) in its classical powder form 5 g twice daily orally, in Group SQBSQ thirty patients with total cholesterol 234 ± 3.822 mg/dl received the SM but in compressed tablet form in the same dosage and in Group SQCSQ 30 patients with total cholesterol 242.7 ± 5.563 mg/dl received atorvastatin 10 mg as a standard control. Follow-up was carried out on second, fourth and 6th week and patients were evaluated on clinical as well as biochemical parameters. Results: Group A before treatment had mean total cholesterol of 243.5 ± 5.294 mg/dl which decreased significantly after treatment to 225.6 ± 5.953 mg/dl (P < 0.001) with a percentage change of 7.35%. Group B had mean total cholesterol of 234 ± 3.822 mg/dl which was significantly reduced to 212.67 ± 3.94 mg/dl (P < 0.001) post-treatment with a percentage change of 9.11%. Control Group C having mean total cholesterol of 242.7 ± 5.563 mg/dl before treatment was significantly decreased to 178.73 ± 4.669 mg/dl (P < 0.001) post-treatment with a percentage change of 26.3%. Group A had significant relief 20.72% (P < 0.001) in fatigue, 16.09% (P > 0.5) relief in palpitation and 26.17% (P < 0.001) relief in dyspnea post-treatment. Group B fatigue decreased significantly by 18.14% (P < 0.01), palpitation by 22.91% (P < 0.01) and dyspnea by 20.46% (P < 0.01). In Group C a non-significant increase of 2.2% was observed in fatigue post-treatment, palpitation decreased by 10.22% non-significantly and dyspnea decreased significantly by 17.64% (P < 0.001). Results indicate that the test drug safely and effectively ameliorates the clinical condition of patients with hyperlipidemia while decreasing cholesterol level as well.


How to cite this article:
Jahangir U, Khan AA, Kapoor P, Jalees F, Urooj S. Evaluation of a classical unani pharmacopeial formulation safoof-e-muhazzil in hyperlipidemia: A randomized, standard controlled clinical study.J Pharm Bioall Sci 2014;6:167-179


How to cite this URL:
Jahangir U, Khan AA, Kapoor P, Jalees F, Urooj S. Evaluation of a classical unani pharmacopeial formulation safoof-e-muhazzil in hyperlipidemia: A randomized, standard controlled clinical study. J Pharm Bioall Sci [serial online] 2014 [cited 2021 Mar 1 ];6:167-179
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2014;volume=6;issue=3;spage=167;epage=179;aulast=Jahangir;type=0