Journal of Pharmacy And Bioallied Sciences

SYMPOSIUM - HERBAL DRUGS AND BOTANICALS - RESEARCH ARTICLES
Year
: 2015  |  Volume : 7  |  Issue : 4  |  Page : 289--292

Antidiabetic activity of ethanolic extract of Cyperus rotundus rhizomes in streptozotocin-induced diabetic mice


Pradeep Singh1, Ratan L Khosa2, Garima Mishra1, Keshri K Jha1 
1 Department of Pharmacognosy, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India
2 Department of Pharmaceutical Sciences, Bharat Institute of Technology, Meerut, Uttar Pradesh, India

Correspondence Address:
Pradeep Singh
Department of Pharmacognosy, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh
India

Objective: In the present investigation, ethanolic extract of Cyperus rotundus (EECR) rhizomes was evaluated for antidiabetic activity in streptozotocin (STZ)-induced diabetic swiss mice. Materials and Methods: After administration of EECR extract for 3 weeks, the body weight, blood glucose, biomarker enzymes (serum glutamic pyruvic transaminase [SGPT] and serum glutamic oxaloacetic transaminase [SGOT]), and plasma lipid levels were measured in STZ-induced diabetic mice. Results: The ethanolic extract at dose levels of 250 and 500 mg/kg body weight revealed significant antidiabetic activity, improvement in body weight, and reduction in elevated biochemical parameters such as SGPT, SGOT, cholesterol, and triglyceride levels. Conclusion: These experimental findings seemed to indicate the use of this plant in traditional Indian medicine for the treatment of diabetes.


How to cite this article:
Singh P, Khosa RL, Mishra G, Jha KK. Antidiabetic activity of ethanolic extract of Cyperus rotundus rhizomes in streptozotocin-induced diabetic mice.J Pharm Bioall Sci 2015;7:289-292


How to cite this URL:
Singh P, Khosa RL, Mishra G, Jha KK. Antidiabetic activity of ethanolic extract of Cyperus rotundus rhizomes in streptozotocin-induced diabetic mice. J Pharm Bioall Sci [serial online] 2015 [cited 2020 Dec 4 ];7:289-292
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2015;volume=7;issue=4;spage=289;epage=292;aulast=Singh;type=0