Year : 2020 | Volume
: 12 | Issue : 5 | Page : 199--203
Characterization and formulation of miswak film for the treatment of chronic periodontitis: An in vitro study
Santhosh Sekar1, Siji Jacob2, Thanga Kumaran Suthanthiran1, Syed Dhasthaheer1, Swathigan Vikraman1, Kanimozhi Kaliappan1
1 Department of Periodontics, JKKN Dental College and Hospital, Komarapalayam, Tamil Nadu, India
2 Department of Periodontics, Rajah Muthiah Dental College and Hospital, Chidambaram, Tamil Nadu, India
Introduction: Miswak is a tooth brushing stick that contains many ingredients that are beneficial for maintenance of oral hygiene. The aim of this study is to formulating a film containing miswak extract for treatment of chronic periodontitis. Materials and Methods: Here we tested the miswak raw extract invitro against Porphyromonas gingivalis and Herpes simplex virus-1 (HSV-1). The film was prepared using solvent casting method. Disintegration test was conducted to find the stability of the film. Results: Cytotoxicity of miswak was also tested. Minimum inhibitory concentration against P. gingivalis was 62.5 µg/mL. Therapuetic index against HSV-1 was 11.3 µg/mL. Cytotoxicity against 50% Vero cells was present at 210 µg/mL. Based on this invitro study 100 µg/mL dose was calculated to be incorporated in a film of size 0.5 mm × 0.4 mm. This film is made of polymers HPMC K 100 and Eudragit L 100. Disintegration test of the film showed that they remained stable for around 5 days. Conclusion: In the present study we formulated the miswak raw extract containing film that can act against P. gingivalis and HSV-1. So it can be used to treat chronic periodontitis by placing it in periodontal pockets.
41, 1st Cross, Balaji Nagar, Ammapet, Salem, Tamil Nadu.
|How to cite this article:|
Sekar S, Jacob S, Suthanthiran TK, Dhasthaheer S, Vikraman S, Kaliappan K. Characterization and formulation of miswak film for the treatment of chronic periodontitis: An in vitro study.J Pharm Bioall Sci 2020;12:199-203
|How to cite this URL:|
Sekar S, Jacob S, Suthanthiran TK, Dhasthaheer S, Vikraman S, Kaliappan K. Characterization and formulation of miswak film for the treatment of chronic periodontitis: An in vitro study. J Pharm Bioall Sci [serial online] 2020 [cited 2020 Oct 27 ];12:199-203
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=5;spage=199;epage=203;aulast=Sekar;type=0