Journal of Pharmacy And Bioallied Sciences

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 12  |  Issue : 5  |  Page : 389--393

A case–control study to evaluate candidal parameters in the oral cavity of patients with type 2 diabetes mellitus


Lakshmanan Vijayalakshmi1, Joseph Babhu Susai Raj2, Jayavel Kavitha3, Selvaraj Krishnaraj3, Balagangadharan Manovijay4, Dhanasekaran Manikandan5 
1 Department of Oral Medicine and Radiology, Rajah Muthiah Dental College and Hospital, Annamalai University, Chidambaram, Tamil Nadu, India
2 Department of Oral Medicine and Radiology, Vivekananda Dental College for Women, Thiruchengode, Tamil Nadu, India
3 Department of Periodontology, Rajah Muthiah Dental College and Hospital, Annamalai University, Chidambaram, Tamil Nadu, India
4 Department of Periodontology, Vinayaka Mission Sankarachariar Dental College, Salem, Tamil Nadu, India
5 Department of Periodontology, CSI College of Dental Sciences, Madurai, Tamil Nadu, India

Correspondence Address:
Lakshmanan Vijayalakshmi
Department of Oral Medicine and Radiology, Rajah Muthiah Dental College and Hospital, Annamalai University, Chidambaram, Tamil Nadu.
India

Aim: The aim of this study was to evaluate candidal parameters in the oral cavity of patients with type 2 diabetes mellitus (DM). Materials and Methods: The samples included in the study were divided into two groups: group A, comprises 50 patients with type 2 DM, and group B, comprises 30 subjects who were nondiabetic. A nonrandom consecutive sampling technique was used to enroll the subjects for the study. The χ2 test was used to examine the characteristics of the samples. Results: The results found that there is a significant difference in saliva and swab for Candida growth between patients with type 2 DM and normal healthy individuals. Swab had shown slightly more Candida growth than saliva in group A (type 2 DM). No significant variation in Candida growth was found. Candida krusei was seen in normal healthy individuals alone. In antifungal susceptibility pattern to various antifungal agents, Candida tropicalis has shown a significant result for various antifungal agents whereas Candida albicans and Candida dubliniensis did not show any significant result for various antifungal agents used in group A (patients with type 2 DM). Conclusion: Diabetic individuals who are prone to a hyperglycemic state favors the growth and establishment of Candida species. Although a smaller percentage of multidrug-resistant Candida species has been observed in the saliva of patients with type 2 DM.


How to cite this article:
Vijayalakshmi L, Raj JB, Kavitha J, Krishnaraj S, Manovijay B, Manikandan D. A case–control study to evaluate candidal parameters in the oral cavity of patients with type 2 diabetes mellitus.J Pharm Bioall Sci 2020;12:389-393


How to cite this URL:
Vijayalakshmi L, Raj JB, Kavitha J, Krishnaraj S, Manovijay B, Manikandan D. A case–control study to evaluate candidal parameters in the oral cavity of patients with type 2 diabetes mellitus. J Pharm Bioall Sci [serial online] 2020 [cited 2021 Apr 18 ];12:389-393
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=5;spage=389;epage=393;aulast=Vijayalakshmi;type=0