Journal of Pharmacy And Bioallied Sciences

REVIEW ARTICLE
Year
: 2020  |  Volume : 12  |  Issue : 5  |  Page : 49--56

Molecular insight into odontogenesis in hyperglycemic environment: A systematic review


Andamuthu Yamunadevi1, Ramani Pratibha2, Muthusamy Rajmohan3, Nalliappan Ganapathy1, Jeyachandran Porkodisudha1, Dhanasing Pavithrah1, Sengottaiyan Mahendraperumal4 
1 Department of Oral Pathology, Vivekanandha Dental College for Women, Namakkal, Tamil Nadu, India
2 Department of Oral Pathology, Saveetha Dental College, Chennai, Tamil Nadu, India
3 Department of Oral Pathology, KSR Institute of Dental Science and Research, Namakkal, Tamil Nadu, India
4 Department of Oral and Maxillofacial Surgery, KSR Institute of Dental Science and Research, Namakkal, Tamil Nadu, India

Correspondence Address:
Andamuthu Yamunadevi
Department of Oral Pathology, Vivekanandha Dental College for Women, Elayampalayam, Namakkal 637205, Tamil Nadu
India

Diabetes mellitus is an endocrinal disorder affecting worldwide and the disease incidence is rising alarmingly high. The effects of diabetes on tooth development are explored by limited studies and their molecular insights are very rarely studied. This systematic review is aimed to provide the best scientific literature source on the molecular insights into odontogenesis in hyperglycemic environment caused by diabetes mellitus or by maternal diabetes on the offspring. The literature search was conducted on the databases, namely PubMed, PubMed Central, Cochrane, and Scopus. The original studies exploring the alterations in the molecular pathways of odontogenesis in diabetes mellitus were selected. Data were extracted, chosen, and evaluated by two independent researchers. At the end of thorough data search, four articles were eligible for the review. Three articles brought out the molecular pathways involved in the offspring of gestational diabetes through animal models. Fourth article was an in vitro study, which treated the stem cells in hyperglycemic environment and drafted the molecular pathway. The altered molecular pathways in dental epithelial stem cells (DESCs), dental papilla cells (DPCs), and stem cells from apical papilla were studied and empowered with statistical analysis. Thus with this systematic review, we conclude that apurinic/apyrimidinic endonuclease1 downregulation causing deoxyribonucleic acid hypermethylation and Oct4, Nanog gene silencing, activation of toll-like receptor-4/nuclear factor kappa B (TLR4/NF-κB) pathway are involved in suppressing cell proliferation and accelerated apoptosis in DESCs in high glucose environment. DPCs are suppressed from odonto differentiation by activation of TLR4 signaling and resulting inhibition of SMAD1/5/9 phosphorylation in diabetic condition. NF-κB pathway activation causes decreased cell proliferation and enhanced differentiation in apical papilla stem cells in hyperglycemia. Further studies targeting various stages of odontogenesis can reveal more molecular insight.


How to cite this article:
Yamunadevi A, Pratibha R, Rajmohan M, Ganapathy N, Porkodisudha J, Pavithrah D, Mahendraperumal S. Molecular insight into odontogenesis in hyperglycemic environment: A systematic review.J Pharm Bioall Sci 2020;12:49-56


How to cite this URL:
Yamunadevi A, Pratibha R, Rajmohan M, Ganapathy N, Porkodisudha J, Pavithrah D, Mahendraperumal S. Molecular insight into odontogenesis in hyperglycemic environment: A systematic review. J Pharm Bioall Sci [serial online] 2020 [cited 2020 Oct 27 ];12:49-56
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=5;spage=49;epage=56;aulast=Yamunadevi;type=0