Journal of Pharmacy And Bioallied Sciences

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 12  |  Issue : 6  |  Page : 737--742

Intraperitoneal antibiotic utilization among continuous ambulatory peritoneal dialysis (CAPD) patients with peritonitis at a tertiary hospital setting in Malaysia


Mastura Ahmad1, Che Suraya Zin1, Ab Fatah Ab Rahman2 
1 Department of Pharmacy Practice, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia
2 Faculty of Pharmacy, Universiti Sultan Zainal Abidin, Besut, Terengganu, Malaysia

Correspondence Address:
Dr. Che Suraya Zin
Department of Pharmacy Practice, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang.
Malaysia

Introduction: Patients receiving continuous ambulatory peritoneal dialysis (CAPD) are commonly associated with peritonitis. However, little is known about the utilization of antibiotics for the treatment of peritonitis in these patients. Objectives: This study aimed to evaluate the patterns of intraperitoneal (IP) antibiotic utilization for the treatment of peritonitis in CAPD patients. Materials and Methods: This is a retrospective study conducted at a tertiary hospital setting in Malaysia. Medical records of CAPD patients who were diagnosed with peritonitis and registered with National Kidney Registry from 2013 to 2018 were reviewed. Types of antibiotics used and its dose and duration were recorded and reported using the anatomical therapeutic chemical/defined daily dose (ATC/DDD) system. Results: A total of 105 peritonitis episodes were recorded from 72 patients. The most common first-line empirical antibiotic combinations used were ceftazidime/cefazolin (40%, n = 42), followed by cefepime/cefazolin (30.5%, n = 32) and ceftazidime/cloxacillin (25.7%, n = 27). The definitive therapy for culture-proven CAPD-related peritonitis (CAPD-P) showed that vancomycin was the most frequently prescribed antibiotic (31.7%, n = 26/82), followed by amikacin (14.6%, n = 12/82), meropenem (11%, n = 9/82) and ampicillin (11%, n = 9/82). Ciprofloxacin was among the least prescribed definitive antibiotics for CAPD-P (2.4%, n = 2/82) but the DDD/100 patient-days estimates showed that it had the highest therapeutic intensity. Conclusion: There are various IP antibiotics used for CAPD-P and the most common empirical therapy was the combination of ceftazidime and cefazolin while vancomycin is predominantly used for definitive therapy. Future studies to evaluate the clinical outcomes of the antibiotic use should be conducted to have a better insight on the efficacy of the peritonitis treatment.


How to cite this article:
Ahmad M, Zin CS, Ab Rahman AF. Intraperitoneal antibiotic utilization among continuous ambulatory peritoneal dialysis (CAPD) patients with peritonitis at a tertiary hospital setting in Malaysia.J Pharm Bioall Sci 2020;12:737-742


How to cite this URL:
Ahmad M, Zin CS, Ab Rahman AF. Intraperitoneal antibiotic utilization among continuous ambulatory peritoneal dialysis (CAPD) patients with peritonitis at a tertiary hospital setting in Malaysia. J Pharm Bioall Sci [serial online] 2020 [cited 2022 Aug 19 ];12:737-742
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=6;spage=737;epage=742;aulast=Ahmad;type=0