Journal of Pharmacy And Bioallied Sciences

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 12  |  Issue : 6  |  Page : 804--809

Knowledge, perception, and antibiotic prescribing practice in the intensive care unit: Findings from the malaysian public setting


Muhammad Azrai Rozali1, Norny Syafinaz Abd Rahman3, Helmi Sulaiman2, Azrin Nurul Abd Rahman3, Nadia Atiya2, Wan Rahiza Wan Mat4, Mohd Fadhil Jamaluddin2, Muhd Zulfakar Mazlan5, Mohd Basri Mat Nor7, Mohd Shahnaz Hasan2, Mohd Hafiz Abdul-Aziz6 
1 Department of Pharmacy Practice, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Malaysia; Department of Intensive Care, International Islamic University Malaysia Medical Centre, Kuantan, Malaysia
2 Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
3 QIMR Berghofer Medical Research Institute, Queensland, Australia
4 Department of Anesthesiology and Intensive Care, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
5 Department of Anaesthesiology and Intensive Care, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia
6 University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland, Queensland, Australia

Correspondence Address:
Muhammad Azrai Rozali
Department of Pharmacy Practice, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang.
Malaysia

Introduction: Approach to managing infection in the intensive care unit (ICU) often varies between institutions and not many readily adapt to available local guidelines despite it was constructed to suite local clinical scenario. Malaysia already has two published guidelines on managing infection in the ICU but data on its compliance are largely unknown. Objectives: A cross-sectional survey was carried out and sent to a total of 868 specialists working primarily in the ICU. The aim of this study was to explore knowledge, perception, and the antibiotic prescribing practice among specialists and advanced trainees in Malaysian ICU. Materials and Methods: A cross-sectional survey was used, consisted of three sections: knowledge, perception, and antibiotic prescribing practice in ICU. Three case vignettes on hospital-acquired pneumonia (HAP), infected necrotizing pancreatitis (INP), and catheter-related bloodstream infection (CRBSI) were used to explore antibiotic prescribing practice. Results: A total of 868 eligible subjects were approached with 104 responded to the survey. Three hundred eighty-nine antibiotics were chosen from seven different classes in the case vignettes. All respondents acknowledged the importance of pharmacokinetic/pharmacodynamic (PK/PD) in antibiotic optimization and majority (97.2%) perceived that current dosing is inadequate to achieve optimal PK/PD target in ICU patients. Majority (85.6%) believed that antibiotic dose should be streamlined to the organisms’ minimum inhibitory concentration (MIC). In terms of knowledge, only 64.4% provided the correct correlations between antibiotics and their respective PK/PD targets. Compliance rates in terms of antibiotic choices were at 79.8%, 77.8%, and 27.9% for HAI, INP, and CRBSI, respectively. Conclusion: Malaysian physicians are receptive to use PK/PD approach to optimize antibiotic dosing in ICU patients. Nonetheless, there are still gaps in the knowledge of antibiotic PK/PD as well as its application in the critically ill, especially for β-lactams.


How to cite this article:
Rozali MA, Abd Rahman NS, Sulaiman H, Abd Rahman AN, Atiya N, Wan Mat WR, Jamaluddin MF, Mazlan MZ, Mat Nor MB, Hasan MS, Abdul-Aziz MH. Knowledge, perception, and antibiotic prescribing practice in the intensive care unit: Findings from the malaysian public setting.J Pharm Bioall Sci 2020;12:804-809


How to cite this URL:
Rozali MA, Abd Rahman NS, Sulaiman H, Abd Rahman AN, Atiya N, Wan Mat WR, Jamaluddin MF, Mazlan MZ, Mat Nor MB, Hasan MS, Abdul-Aziz MH. Knowledge, perception, and antibiotic prescribing practice in the intensive care unit: Findings from the malaysian public setting. J Pharm Bioall Sci [serial online] 2020 [cited 2022 Aug 8 ];12:804-809
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=6;spage=804;epage=809;aulast=Rozali;type=0