Journal of Pharmacy And Bioallied Sciences

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 13  |  Issue : 1  |  Page : 26--30

Provision of standardized all-in-one parenteral nutrition (AIO-PN) for very preterm neonates: Evaluation at room and cold temperatures


Suci Hanifah, Yuli Maulidani, Bambang Hernawan Nugroho, Chynthia Pradiftha Sari 
 Department of Pharmacy, University of Islam Indonesia, Yogyakarta, Indonesia

Correspondence Address:
Dr. Chynthia Pradiftha Sari
Department of Pharmacy, Universitas Islam Indonesia, Yogyakarta 55584.
Indonesia

Introduction: All-in-one parenteral nutrition (AIO-PN) is essential for patients with limited venous access, e.g. premature infants. So far, there are still some conflicting data related to the stability of AIO-PN. The aim of this study is to examine the physical stability and sterility of AIO-PN as it was being stored at room and cold temperature. Materials and Methods: AIO-PN contains dextrose, amino acid, lipid, sodium chloride, magnesium sulfate, potassium chloride, calcium gluconate, and vitamin. Formulation of AIO-PN was prepared based on the guidance of nutrition for 3-day-old preterm baby weighing 1000 g. The formulation of AIO-PN then was stored at room temperature (25.43ºC ± 0.54) and cold temperature (6.2ºC ± 2.04). Results and Discussion: Based on the experiments, all formulas confidently fulfilled the sterile criteria, in which there is no microbial growth in the formula within 7 days. During those days, the droplet size of all formulas was under the range (<500 nm) with a good range of pH. However, during the process of storing under the room temperature, AIO-PN showed the reversible creaming starting on day 2 and the discoloration starting on day 4. Meanwhile, we found that there are no such physical changes in the formula within 7 days under the cold temperature. Conclusion: This research confirmed that AIO-PN that is being stored at room temperature cannot be used starting on day 4, but the formulation storage under the cold temperature is still accepted within 7 days.


How to cite this article:
Hanifah S, Maulidani Y, Nugroho BH, Sari CP. Provision of standardized all-in-one parenteral nutrition (AIO-PN) for very preterm neonates: Evaluation at room and cold temperatures.J Pharm Bioall Sci 2021;13:26-30


How to cite this URL:
Hanifah S, Maulidani Y, Nugroho BH, Sari CP. Provision of standardized all-in-one parenteral nutrition (AIO-PN) for very preterm neonates: Evaluation at room and cold temperatures. J Pharm Bioall Sci [serial online] 2021 [cited 2021 Apr 21 ];13:26-30
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=1;spage=26;epage=30;aulast=Hanifah;type=0