Journal of Pharmacy And Bioallied Sciences

: 2021  |  Volume : 13  |  Issue : 5  |  Page : 6--10

Fibroblastic growth factor as a diagnostic and prognostic marker in odontogenic cysts and tumors: A systematic review

Gururaj Narayana Rao1, Adlin Saroja Rosaian1, Gowthami Jawahar1, P Hari Nivas Raj1, J Beryl Rachel1, P Blessing Emmanuel2,  
1 Department of Oral and Maxillofacial Pathology, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India
2 Peterson Dental Clinic, Tenkasi District, Tamil Nadu, India

Correspondence Address:
Gururaj Narayana Rao
Department of Oral and Maxillofacial Pathology, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu


Cellular signaling proteins maintain the basic activities of cell and communication, between the cells for normal growth and development and pathological situation as well. Fibroblast growth factor (FGF) and fibroblast growth factor receptors (FGFRs) have a comparatively huge part to play in the cellular communication processes. Human FGF has 22 members, 18 ligands, and 4 tyrosine kinase receptors for binding and is expressed in a wide range of cells. Any alteration in these factors would disrupt their normal function, leading to various abnormalities. The aim of this systematic analysis, is to understand the FGFs, the physiological and pathological role of FGF in oral diseases, and to predict the use of FGF in the predilection toward odontogenic cyst and tumors. This review helps confer the role of FGF in various physiological and pathological aspects in systemic diseases and analyzes its role in diagnosis and prognosis of odontogenic cysts and tumors.

How to cite this article:
Rao GN, Rosaian AS, Jawahar G, Raj P H, Rachel J B, Emmanuel P B. Fibroblastic growth factor as a diagnostic and prognostic marker in odontogenic cysts and tumors: A systematic review.J Pharm Bioall Sci 2021;13:6-10

How to cite this URL:
Rao GN, Rosaian AS, Jawahar G, Raj P H, Rachel J B, Emmanuel P B. Fibroblastic growth factor as a diagnostic and prognostic marker in odontogenic cysts and tumors: A systematic review. J Pharm Bioall Sci [serial online] 2021 [cited 2022 Jul 7 ];13:6-10
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Full Text


Fibroblast growth factors (FGFs) are proteinaceous substances that act in many biological, physiological, functional, and developmental processes.[1] FGF ligands in combination with fibroblast growth factor receptors (FGFRs, respective receptors) exhibit various controlled signaling pathways that bring about specific and regulated cellular responses. Any type of modification or mutation that causes changes in the FGF/FGFR signaling results in various types of abnormalities.[1] Point mutations, genetic alterations, and other related chromosomal aberrations that result in splice variants and altered FGFs have the potential to form cancer.[2] In the investigative protocols using the generation sequencing technique, conclusive results showed that a small amount (7% of cancers) is characterized by FGF–FGFR gene alterations. These include around 66% of lesions, which are caused because of FGFR–FGF gene amplification, 26% due to gene mutations, and 8% caused because of gene rearrangements. Although the role of FGF in the odontogenic cysts and tumors was studied by various authors, they are yet to establish its genetic predisposition.[3] Therefore, we have planned to do a cumulative study that would focus on the genetic predisposition. The review analyzes the role of FGF in various odontogenic lesions studies so far and the possibility of using it as a predictive, diagnostic, and prognostic marker.


The aim of this study is to understand the FGFs and its physiological and pathological role of FGF in oral diseases, based on the analysis of the collected articles, and to predict the use of FGF in the predilection toward odontogenic cyst and tumors

 Materials and Methods

This systematic review was analyzed in accordance with Preferred Reporting Items for Systematic reviews and Meta-Analyses Statement Criteria (Moher, Liberati, Tetzlaff, Altman, and PRISMA Group, 2010) [Figure 1].{Figure 1}

Inclusion criteria

In this review, we included full papers available in the English literature that were published after 1980; all peer-reviewed articles; observational studies such as cohort, case–control, and retrospective studies; all the articles that used to know the physiological and pathological role in oral diseases; and clinical and research-oriented application in oral lesions. Thus, we included those articles that used to predict the use of FGF in determining genetic predisposition.

Exclusion criteria

All the duplicates and abstract-only articles were excluded. Articles that used markers only to diagnose epithelial neoplasm were also excluded.

Sources, search strategy, and study selection

Cochrane Database of Systematic Reviews, Embase, Medline, Sci-Expanded, PubMed, and PubMed Central were searched to identify the records relating to this review.


The systematic analysis shows the role of fibroblastic growth factor in physiological and pathological processes (as Tabulated in [Table 1], [Table 2], [Table 3], [Table 4]){Table 1}{Table 2}{Table 3}{Table 4}.


FGF has a very important role to play in every aspects of embryogenesis, and its manifestation is highly appreciable in the growth and development of an individual. FGF and the FGFR ligands along with their signaling network play an important role in the process of odontogenesis.[4],[5]

At the initiation stage, once enamel formation begins following the signals from odontogenic epithelium, FGF 8, FGF 9, and FGF 17 are expressed.[6],[7],[8],[9],[10] Similarly, FGF 10 is expressed in the mesenchyme, during the initial phases of the formation of dentin and surrounding bony arrangement.[5],[11],[12,[13],[14],[15] The overall physiological role of each FGF is tabulated in Table 3.

A comprehensive collection of studies showing mutation of the FGF gene and the pathologies involved is analyzed in Table 2 and its clinical applications is summarized in Table 4.

From the review, we could identify that FGF 1, FGF 2, and FGF 8 are studied in the odontogenic tumors and cyst.

However, the role of FGF in odontogenic cyst and tumors as effective as a diagnostic, prognostic, and predictive biomarker is yet to be studied. Further, it is much more evocative to identify its role as a predictive marker in the odontogenic tumors and odontogenic cysts.

Limitations and future perspective

The protagonist action of FGF as a biomarker for the genetic predisposition of odontogenic tumors and odontogenic cysts is still inconclusive. Thus, studies conducting on a large scale using FGF in the dental follicle and odontogenic epithelium surrounding the impacted tooth may be beneficial in predicting the pathological changes.


This systematic review gives an insight into the physiological role of Fibroblastic Growth Factor, and the pathologies that are associated with the various gene alterations. Such analysis helps in diagnosis and determining the prognosis of various Odontogenic cysts and tumors.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.


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