Journal of Pharmacy And Bioallied Sciences

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 13  |  Issue : 6  |  Page : 1124--1130

Histocompatibility of dental restorative composite resin photopolymerized with a novel multifunctional comonomer: A histopathological analysis in rats


Jambai Sampathkumar Sivakumar1, Ranganathan Ajay2, Karuppiah Gokulapriyan3, Natesan Thangaraj Deepa4, Subramaniam Kalaiyarasu Vigneshwari5, Shafie Ahamed6 
1 Department of Conservative Dentistry and Endodontics, Vivekanandha Dental College for Women, Tamil Nadu, India
2 Department of Prosthodontics and Crown & Bridge, Vivekanandha Dental College for Women, Tamil Nadu, India
3 Department of Conservative Dentistry and Endodontics, CSI College of Dental Sciences and Research, Tamil Nadu, India
4 Department of Conservative Dentistry and Endodontics, KSR Institute of Dental Sciences and Research, Tamil Nadu, India
5 Department of Conservative Dentistry and Endodontics, Indira Gandhi Institute of Dental Sciences, Pondicherry, India
6 Department of Conservative Dentistry and Endodontics, Rajah Muthiah Dental College and Hospital, Tamil Nadu, India

Correspondence Address:
Jambai Sampathkumar Sivakumar
Department of Conservative Dentistry and Endodontics, Vivekanandha Dental College for Women, Elayampalayam, Tiruchengode, Namakkal - 637 205, Tamil Nadu
India

Background: Restorative dentistry is impossible without composite resins. Toxicity of these resins is common though possessing favorable properties. Modifications of the resin matrix are being executed to improve the properties of the material. Dipentaerythritol penta-/hexa-acrylate (DPEPHA) monomer has been recently identified as a cross-linking comonomer with the conventional resin matrix. Purpose: This study aimed to investigate the histocompatibility of DPEPHA comonomer in photopolymerized resin at 20 and 40 wt.% concentrations in rats. Materials and Methods: Eighteen male Wister rats were subjected to subcutaneous implantation of conventional resin specimens without DPEPHA (G0) and with DPEPHA at 20 wt.% (G20) and 40 wt.% (G40) concentrations. Then, the rats were subdivided according to the time of resection of the implantation sites at 1, 2, and 4 weeks (n = 6 rats). Tissue specimens were submitted to histopathological analysis. Results: Except for 4 weeks' time interval, there were significant differences (P < 0.05) in the inflammation among the groups at each time interval. The order of inflammation was NC <G40 ≤G20 <G0. Concerning the fibrous capsule thickness, significant difference existed among the groups at each time interval and within the groups at all 3 time intervals (P < 0.05). Conclusion: Composite resin specimens with DPEPHA comonomer exhibited good histocompatibility in rats at 40 wt.% concentration.


How to cite this article:
Sivakumar JS, Ajay R, Gokulapriyan K, Deepa NT, Vigneshwari SK, Ahamed S. Histocompatibility of dental restorative composite resin photopolymerized with a novel multifunctional comonomer: A histopathological analysis in rats.J Pharm Bioall Sci 2021;13:1124-1130


How to cite this URL:
Sivakumar JS, Ajay R, Gokulapriyan K, Deepa NT, Vigneshwari SK, Ahamed S. Histocompatibility of dental restorative composite resin photopolymerized with a novel multifunctional comonomer: A histopathological analysis in rats. J Pharm Bioall Sci [serial online] 2021 [cited 2022 Oct 5 ];13:1124-1130
Available from: https://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=1124;epage=1130;aulast=Sivakumar;type=0